Guide to Chiome Bioscience

Guide to Chiome Bioscience

  • 1. Chiome’s Goal
  • 2. Contributing to Antibody Drugs and Antibody Drug Discovery
  • 3. Strengths of the ADLib® System
  • 4. Business Model
  • 5. Chiome’s Potential by Numbers

“Antibody drugs” use the body’s own immune system to attack specific cells. Antibody drugs are predicted to show 10% annual growth.

Unlike small-molecule drugs, antibody drugs are revolutionary drugs that use the body’s own immune system to target and destroy specific cells such as cancer cells. Antibody drugs are attracting massive attention thanks to features such as low adverse effect profile and effectiveness for diseases that previously had no therapy. Antibody drugs promise to revolutionize health care.

* What is an antibody drug?
Humans are equipped with a defensive system that recognizes protein from bacteria, viruses, etc. as foreign substances (antigens) and attacks these foreign substances with antibody protein (the antigen-antibody reaction). Drugs that make use of this inherent reaction in humans are called antibody drugs. Antibody drugs have drawn attention as effective therapies that cause few adverse effects. This is because they do not attack normal cells along with disease cells as is the case with conventional anticancer and other drugs. The first antibody drug was created when serum collected from rabbits infected with Clostridium tetani was injected into experimental animals.

The Marketability of Antibody Drugs

Antibody Drugs: Promising Products with a Low Adverse Effect Profile

From prevention (vaccines) to treatment, antibody drugs enlist the body’s innate defense system and antibodies to treat various diseases. These new drugs are attracting attention, and their potential for growth is increasing dramatically. Antibody drugs have the three following features.

  1. Directly hitting their target, e.g., pathogen
  2. A low adverse effects profile
  3. Prolonged effect

Antibody Drugs Are Predicted to Show 10% Annual Growth

Research and development on antibody drugs have been kicked into gear in 2000. As of November 2014, 47 therapeutic antibody drugs were on the markets in Europe and the U.S. Given the recent trend of approving four new therapeutic antibody drugs and released onto markets on an average annual basis, the antibody pharmaceuticals market is expected to see stable growth with 70 therapeutic antibody drugs placed on the market by 2020.

Using Antibodies That Protect the Body from Foreign Substances to Treat Cancer and Other Diseases

Antibody drugs promise to be extremely effective for diseases that present highly specific targets, but no effective treatments have neen available. Antibody drugs promise to provide treatments for diseases such as infections, central nervous system diseases, and allergic diseases.

• Antibody drugs are used chiefly for:
Type of disease Inflammation and autoimmune disease
Oncology Colon cancer, Breast cancer, Non-small cell lung cancer, Melanoma, Renal cell carcinoma, Acute myeloid leukemia, non-Hodgkin’s lymphoma
Immunology and Allergy Rheumatoid arthritis, Crohn’s disease, Castleman’s disease, Asthma, Acute graft rejection following renal transplantation
Others Age-related macular degeneration, Osteoporosis, infection