Engineering the Next Dimension
of Antibody Therapeutics
DoppeLib™ is a high-throughput discovery engine for multispecific and biparatopic antibodies
— enabling screening directly in final therapeutic formats.
The Complexity Dilemma
Multispecific and biparatopic antibodies promise superior therapeutic activity, yet their structural complexity limits scalable discovery.
200 × 200 = 40,000
Unlocking combinatorial scale is the key to next-generation biologics.
Technology Deep Dive
Level 1 — Why DoppeLib™ Is Differentiated
Multiple Final Formats
Structurally complex multispecific and biparatopic architectures evaluated directly in relevant configurations.
Dual Expression
Simultaneous membrane and secreted expression streamlines evaluation.
Scalable Combinatorics
Unlock large parental antibody combination space efficiently.
Level 2 — Platform Architecture & Workflow
Combinatorial Library Generation
Integrated pooled vector systems create structurally diverse combinatorial libraries via proprietary display platforms.
Dual Expression System
Simultaneous display and secretion enables rapid screening and downstream validation.
Functional-Driven Selection
Prioritize biologically meaningful activity for optimized therapeutic candidates.
Level 3 — Technical Evaluation
Detailed datasets and technical documentation available under CDA.